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desvenlafaxine will improve the stage or impact of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Warning/Check. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, four hundred mg) minimize the CYP2D6 substrate dose by around fifty%; no dosage adjustment needed with desvenlafaxine doses seven consecutive days quickly

clomipramine decreases results of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep an eye on. Stops conversion of codeine to its Lively metabolite morphine.benzhydrocodone/acetaminophen and codeine both enhance sedation. Prevent or Use Alternate Drug. Restrict use to sufferers for whom substitute procedure selections are insu